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The Effect Of Ethanol Extract Of Desmodium Velutinum Stem On Some Marker Emzyme In Liver Of Albino Wistar Rats
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CHAPTER ONE
INTRODUCTION
The liver is the largest and most complex internal organ in the body. It plays an important role in the maintenance of internal environment through its multiple and diverse functions. Liver is involved in several vital functions such as metabolism, secretion and storage. Hepatitis or inflammatory disorder involves inflammation and change to the hepatocytes. Hepatitis is one of the most prevalent diseases in the world. Every year 18,000 people had been reported to die due to liver cirrhosis caused by viral hepatitis (Wang et al., 2008). Ectopic fat storage occurs in obesity, particularly in the liver leading to a condition termed non alcoholic fatty liver disease (NAFLD) characterized by varying degree of liver injury that progresses from steatosis to tratohepatitis, fibrosis and necrosis. Due to its prominent association with insulin resistance/obesity, NAFLD is regarded as the hepatic manifestation of metabolic syndrome. Liver has great capacity to detoxicate toxic substance and synthesizes useful principles. Therefore damage to liver inflicted by hepatotoxic agents is of grave consequences. Experimental studies have reported that animal fed a high fat diet (HFD) for more than two months develop weight, hyperlipidemic, hyperglycemia, oxidative stress and insulin resistance (IR). Besides, consumption of a calorie-rich diet results in lipid accumulation, excess production of inflammatory cytokines and macrophage infiltration that favours the progression of liver disease. Many medicinal plant/indigenous plant have been mentioned and well established as hepatoprotective agents.
Desmodium velutinum is a medicinal plant around the world. The extract of Desmodium velutinum showed significant anti-pyretic activity on experimental rats used. Desmodium velutinum is very rich in alkaloids and related amino compounds. It is a source of flavonoid, saponins and pharmacological active agent useful in the treatment of aches and pains. It also showed that one of the uses is for erectile enhancing property.
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ABSRACT - [ Total Page(s): 1 ]Present investigations were carried out on the effect of ethanol extract of Desmodium velutinum stem on some liver enzymes of albino wistar rats fed with high fat from cow‟s brain. Twelve healthy albino wistar rats were divided into four groups. Group I rats were fed with balanced diet (normal feed, that is grower‟s mash) and tap water. Group II rats were fed with fat diet (cow‟s brain) (3.6g/day) alone. Group III rats received combined mixture of 70% fat diet (cow‟s brai ... Continue reading---
