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The Effect Of Ethanol Extract Of Desmodium Velutinum Stem On Some Marker Emzyme In Liver Of Albino Wistar Rats
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Desmodium velutinum being one of the important medicinal plant in the
world may have effect on the liver. However limited studies are
available on the effect of Desmodium velutinum treatment on
hepatoprotective effect of its extract on high fat diet fed animal. In
this regard, the present study was aimed to investigate the effect of
ethanol extract of Desmodium velutinum stem on liver function tests on
albino wistar rats fed with high fat from cow‟s brain related to
different hepatoprotective effect by comparing it to a known drug,
atorvastatin treatment which is used to lower the level of cholesterol
in blood. Since changes in the concentration and composition of plasma
lipid and lipoproteins occur frequently in liver disease, these findings
may be useful in following the clinical course of patient with liver
diseases of various causes.
Liver disease is associated with
characteristic changes in the lipid composition of the surface coat of
plasma lipoprotein particles. Cholesterol accumulate as hepatic
secretion of lecithin cholesterol acyltransferase decreases, such
abnormal circulating lipoproteins tend to induce corresponding changes
in cell membrane lipid composition. Studies in both human and
experimental liver disease confirm that this does occur and that it is
wide-spread. Low density lipoproteins, which are rich in cholesterol can
also be taken up by the liver or extrahepatic tissues by a receptor
mediated endocytosis that specially recognizes apolipoproteins. It can
be predicted that extra hepatic membrane dysfunction might be a general
feature of severe liver disease. It is proposed that many of the
cellular disturbances and metabolic abnormalities accompanying hepatic
disease result from, or are exacerbated by lipoprotein induced changes
in membrane lipid composition and function. Hence Desmodium velutinum
may be a source of a pharmacological active agent useful in the
treatment of high level cholesterol in the blood which has got both
liver protecting and nutritional value.
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ABSRACT - [ Total Page(s): 1 ]Present investigations were carried out on the effect of ethanol extract of Desmodium velutinum stem on some liver enzymes of albino wistar rats fed with high fat from cow‟s brain. Twelve healthy albino wistar rats were divided into four groups. Group I rats were fed with balanced diet (normal feed, that is grower‟s mash) and tap water. Group II rats were fed with fat diet (cow‟s brain) (3.6g/day) alone. Group III rats received combined mixture of 70% fat diet (cow‟s brai ... Continue reading---
