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Hypolipidemic And Antioxidant Capacity Of Methanol Leaf Extract Of Kigelia Africana In Alloxan Induced Diabetic Albino Rats
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Title page
Certification Page
Approval page
Dedication
Acknowledgement
Abstract
Table of contentCHAPTER ONE
1.1 Background of study
1.2 Statement of the problem
1.3 Aim of the study
1.4 Objectives of the studyCHAPTER TWO
LITERATURE REVIEW2.1 General information
2.2 Origin and geographical distribution
2.3 Scientific classification
2.4 Medical benefits of kigelia Africana
2.4.1 Antibacterial and antifungal
2.4.2 Alternative uses of kigelia Africana
2.4.3 Chemical constituents of kigelia Africana
2.5 Alloxan
2.5.1 Chemical structure of alloxan
2.5.2 Mechanism of alloxan
2.5.3 Chemical properties of alloxan
2.5.4 Impact of alloxan upon beta cells
2.6 Diabetes mellitus
2.6.1 Types ofdiabetes
2.6.2 Risk factors of diabetes
2.7 Hypolipidermia
2.7.1 Lipid peroxidation
2.8 AntioxidantCHAPTER THREE
MATERIALS AND METHODS3.1 Chemical and reagents
3.2 Equipments
3.3 Materials
3.4 The plant
3.4.1 Extract preparation
3.4.2 Prepration of extract for administration
3.5 Experimental animal
3.5.1 Animal separation, induction and treatment measures
3.6 Determination of biochemical parameters
3.6.1 Determination of total protein concentration
3.6.2 Determination of lipid peroxidation (malondialdehyde)
3.6.3 Determination of glutathione peroxidase(GPX)
3.6.4 Determination of triacylglycerides(TAG)
3.6.5 Determination of the glucose levelCHAPTER FOUR
4.0 RESULTS
4.1 Triacylglycerides
4.2 Total protein
4.3 Glutathione peroxidase
4.4 Malondialdehyde
4.5 Percentage yield for extract
4.6 Reading for glucose testCHAPTER FIVE
5.1 Disscussion
5.2 Conclusion
5.3 Recommendation
5.3 ReferencesAPPENDIX
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ABSRACT - [ Total Page(s): 1 ]Diabetic mellitus is a metabolic disorder resulting from a defect in insulin secretion , insulin action or both . The deficiency of insulin leads to chronic hyperglycemia with disturbances of carbohydrate , fats and protein metabolism. Kigelia Africana is a sausage tree known to have medicinal values. The aim of this work is to evaluate the hypolipidemic and antioxidant capacity of the plant , methanol leaf extract of kigelia Africana which was used for the study. The leaves were ground into a ... Continue reading---
CHAPTER ONE - [ Total Page(s): 1 ]INTRODUCTION1.1 BACKGROUND OF STUDYDiabetes mellitus is a metabolic disorder resulting from a defect in insulin secretion, insulin action or both. Insulin deficiency in turn leads to chronic hyperglycemia with disturbances of carbohydrate, fat and protein metabolism (Kumar et al., 2011). During diabetes, failure of insulin-stimulated glucose uptake by fat and muscle cause glucose concentration in the blood to remain high, consequently glucose uptake by insulin independent tissue increases. Incre ... Continue reading---
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ABSRACT - [ Total Page(s): 1 ]Diabetic mellitus is a metabolic disorder resulting from a defect in insulin secretion , insulin action or both . The deficiency of insulin leads to chronic hyperglycemia with disturbances of carbohydrate , fats and protein metabolism. Kigelia Africana is a sausage tree known to have medicinal values. The aim of this work is to evaluate the hypolipidemic and antioxidant capacity of the plant , methanol leaf extract of kigelia Africana which was used for the study. The leaves were ground into a ... Continue reading---
TABLE OF CONTENTS -- [Total Page(s) 1]
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TABLE OF CONTENTS -- [Total Page(s) 1]
Page 1 of 1