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RELATIONSHIP BETWEEN ANAEMIA, GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY AND OXIDATIVE STRESS AMONG MALARIA PATIENTS VISITING ESUT TEACHING HOSPTIAL ENUGU NIGERIA
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ABSRACT - [ Total Page(s): 1 ]Malaria is a significant public health problem in the world especially in in sub-Saharan Africa. One of the key contributory factors to the development and progression of malaria and its complications is oxidative stress, a condition characterized by increased production of free radicals or impaired antioxidant defence system. Glucose-6-phosphate dehydrogenase (G-6-PD) produces NADPH which intends regenerate reduced glutathione (GSH), an antioxidant which helps in the removal of free radicals thereby preventing oxidative stress, Hence, this study was aimed to investigate the relationship bet
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CHAPTER ONE - [ Total Page(s): 2 ]Proteins are the largest constituent of the cellular milieu and are frequent targets of oxidative damage (Stadtman, 2004). Protein oxidation can involve direct reaction with amino acids, cleavage of the polypeptide chain, and conversion of the protein to derivatives that are highly sensitive to proteolytic degradation. It has also been established that all of these protein modifications can be mediated by metal-catalyzed oxidation systems. All amino acid residues of proteins are potential targets for oxidation by HO· or by H2O2 in the presence of metal ions. For example, oxidation of tyrosi ... Continue Reading
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ABSRACT - [ Total Page(s): 1 ]Malaria is a significant public health problem in the world especially in in sub-Saharan Africa. One of the key contributory factors to the development and progression of malaria and its complications is oxidative stress, a condition characterized by increased production of free radicals or impaired antioxidant defence system. Glucose-6-phosphate dehydrogenase (G-6-PD) produces NADPH which intends regenerate reduced glutathione (GSH), an antioxidant which helps in the removal of free radicals thereby preventing oxidative stress, Hence, this study was aimed to investigate the relationship bet
... Continue Reading
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