The Effect Of Antidiabetic Agent Glibenclamide And Meltformine On Lipids And Glycated Haemoglobin In Type 2 Diabetes Patient Attending Uith Ilorin

CHAPTER FOUR
4.0    RESULTS
Out of the 90 subjects recruited for this project, 60 were type 2 diabetic individuals and 30 were used as controls with age ± SEM 47.9 ± 2.22 and 55.86 ± 12.08 years respectively. Among the 60 subjects with type 2 diabetic males are 32 (53.3%) while females are 28 (46.7%) (Table 4.1).
Comparison of anthropometric indices between diabetic patient using antidiabetic drugs (Metformin and Glianpride cases) and non-diabetic patients (control) shows a significant different in height weigh and BMI. (Table 4.2)
Comparison of biochemical parameters (T. cholesterol, glycated, triglycerides, Low Density Lipoprotein, High Density Lipoprotein) and fasting blood sugar) in diabetic patient (cases) using antidiabetic drugs (Metformin and Glianpride) and non-diabetic patients (control) shows that the mean value of HbA1c and FBG were significantly higher (P<0.05) in subjects in comparison to controls. Among the circulating lipids, TC and LDL-C were significantly higher (P<0.05) in tests. Although the mean level of TG was slightly lower and of HDL-C slightly higher in controls than type 2 individual, these differences were statistically non-significant which in accordant with stamouli et al., 2014 that says the combination of elevated TRG and reduced HDL-C was the most prevalent of the combined lipid abnormalities in type 2 individual. (Table 4.3).
Comparison of biochemical parameters (T. cholesterol, High Density Lipoprotein, Low Density Lipoprotein, triglycerides, glycated, and fasting blood sugar) between diabetic patient on Metformin alone and diabetic patients on combined Metformin and Glianpride shows no significant in FBS and HDL-C with significant different in other parameters was in line the paper published by Stratton et al. (2002) (Table 4.4)
Comparison of biochemical parameters (T. cholesterol, High Density Lipoprotein, Low Density Lipoprotein, triglycerides, glycated, and fasting blood sugar) in diabetic patient (cases) (using both Metformin and Glianpride, and also Metformin alone), shows no significant in all the biochemical parameters in respect with the duration of the illness (Duration of managing Diabetes) (Table 4.5)
Correlation of Duration in Diabetes and BMI with biochemical parameters (T. cholesterol, High Density Lipoprotein, Low Density Lipoprotein, triglycerides, glycated, and fasting blood sugar) in Diabetic patient using antidiabetic drugs (Metformin and Glianpride) shows significant in all the biochemical parameters excepts TG which explains tendency of type 2 diabetic individual prone to diabetic complications which was discordant with Meena et al. (2006) that says the results obtained indicated that the HbA1c levels showed a significant increase with the duration of diabetes as well as the insulin level showed a significant correlation after adjustment for age, sex and duration of diabetes (Table 4.6).