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The Antiplasmodial Activity Of Extracts Of Edible Mushroom: Agaricus Bisporus On Plasmodium Berghei In Albino Mice
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The temperature of the mice as the experiment progressed showed that the infection of the mice caused a reduction in the temperature of the mice. Most of the mice had an average temperature of 36.8±1.22°C before the commencement of the experiment. However, as the experiment proceeds, there was decrease in their body temperature. The group that was infected and treated with placebo (negative control) had a temperature as low as 34.2±0.20°C. It was observed that higher concentration (400mg/ml) of the aqueous mushroom extract caused an increase in temperature from 36.6±0.90°C to 36.8±0.04°C; about 0.5% increase. Other concentrations brought about a reduction in the temperature of the mice (Table 3).
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ABSRACT - [ Total Page(s): 1 ]ABSTRACT IS COMING SOON ... Continue reading---
CHAPTER ONE - [ Total Page(s): 2 ]1.4 Aim and Objectives1.4.1 AimTo determine the antiplasmodial activity of extracts of edible mushroom: Agaricus bisporus on Plasmodium berghei in albino mice.1.4.2 ObjectivesThe specific objectives of this study were to:a. assess the analytical components of edible mushroom (Agaricus bisporus) using Gas Chromatography Mass Spectrophotometry (GCMS).b. determine the antiplasmodial activity of edible mushroom extract: (Agaricus bisporus) on Plasmodium berghei.c. ... Continue reading---
CHAPTER TWO - [ Total Page(s): 4 ]HPLC-based activity profiling and subsequent chromatography of the ethyl acetate extract of Ganoderma lucidum yielded six lanostanes (106–112) of which three (107, 108, 112) were new (Fig. 1). These lanostanes exhibited moderate in vitro antiplasmodial activity with IC50 values of 6 to 20 Μm (Adams et al., 2010). Investigation of the chemical constituents of fungus, Cordyceps nipponica BCC 1389 led to the identification of four isolates of N-hydroxy- and N-methoxy-2-pyridones compounds ... Continue reading---
CHAPTER THREE - [ Total Page(s): 2 ]CHAPTER THREE3.0 MATERIALS AND METHODS3.1 Sample Collection Sufficient mushrooms (Agaricus bisporus) was gotten from Igunsin village, Akure north in Ondo State, Nigeria and taken to the Herbarium Service Unit (HSU), Department of Plant Biology, University of Ilorin, Ilorin, Kwara State, Nigeria for authentication with a voucher number of F.H.I. 11295.3.2 Drying and ExtractionThe mushroom samples were cut into pieces using a sharp knife. The pieces were air-dried properly ... Continue reading---
CHAPTER FIVE - [ Total Page(s): 2 ]CHAPTER FIVE5.0 DiscussionThis result of the Gas Chromatograghy Mass Spectrophotometry identified the compounds present in the fruiting body of A. bisporus. The prevailing compounds in the aqueous extract were 1-Butanamine, 2-methyl-N- (2-methylbtylidene) (2.03%), 2-Pyrorolidinone (7.46%) while the prevailing compounds in the alcoholic extract were n-Hexadecanoic acid (19.47%) and 9,12-Octadecadienoic acid (Z,Z) (80.53%). According to Isaka et al. (2001), these are some of the active ingre ... Continue reading---
REFRENCES - [ Total Page(s): 2 ]REFERENCESAdams, M., Christen, M., Plitzko, I., Zimmermann, S., Brun, R., Kaiser, M., Hamburger, M. (2010) Antiplasmodial lanostanes from the Ganoderma lucidum mushroom. Journal of Natural Products, 73:897–900.Akindahunsi, A. A., and Oyetayo, F. L. (2012). Nutrient and anti-nutrient distribution of edible mushroom, Pleurotus tuberregium (Fries) Singer. Food Science and Technology, 39(5):548-553.Anthony, M.P., Burrows, J.N., Duparc, S., Moehrle, J.J.,Wells, T.N.C. (2012) The global pipelin ... Continue reading---
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