-
The Antiplasmodial Activity Of Extracts Of Edible Mushroom: Agaricus Bisporus On Plasmodium Berghei In Albino Mice
CHAPTER FIVE -- [Total Page(s) 2]
Page 2 of 2
-
-
-
5.1 Conclusion
Agaricus bisporus used in this research revealed medicinal property that could suppress malaria parasites in-vivo and that the hot water extract of the mushroom exerted a higher percentage suppression.
Therefore, the consumption of A. bisporus is highly encouraged as it will help suppress or prevent malaria parasites.
5.2 Recommendations
Pharmacological effects of A. bisporus and other mushroom products on the human body must be ascertained, toxicological studies should be performed, authenticity should be verified, and quality control standards should be maintained to ensure both maximal safety and efficacy to treat malaria and probably other chronic and acute conditions. Modern scientific methodology and medicinal chemistry approaches will continue to identify and evaluate the bioactive components found in phytochemical prescriptions, and validate their use as sources of new, effective, and safe world-class new medicines and dietary supplements.
Further analysis on the active components in A. bisporus that displayed antiplasmodial property should be extracted, purified and incorporated into antimalarial drugs, thereby reducing the menace of Plasmodium resistance.
CHAPTER FIVE -- [Total Page(s) 2]
Page 2 of 2
-
-
ABSRACT - [ Total Page(s): 1 ]ABSTRACT IS COMING SOON ... Continue reading---
CHAPTER ONE - [ Total Page(s): 2 ]1.4 Aim and Objectives1.4.1 AimTo determine the antiplasmodial activity of extracts of edible mushroom: Agaricus bisporus on Plasmodium berghei in albino mice.1.4.2 ObjectivesThe specific objectives of this study were to:a. assess the analytical components of edible mushroom (Agaricus bisporus) using Gas Chromatography Mass Spectrophotometry (GCMS).b. determine the antiplasmodial activity of edible mushroom extract: (Agaricus bisporus) on Plasmodium berghei.c. ... Continue reading---
CHAPTER TWO - [ Total Page(s): 4 ]HPLC-based activity profiling and subsequent chromatography of the ethyl acetate extract of Ganoderma lucidum yielded six lanostanes (106–112) of which three (107, 108, 112) were new (Fig. 1). These lanostanes exhibited moderate in vitro antiplasmodial activity with IC50 values of 6 to 20 Μm (Adams et al., 2010). Investigation of the chemical constituents of fungus, Cordyceps nipponica BCC 1389 led to the identification of four isolates of N-hydroxy- and N-methoxy-2-pyridones compounds ... Continue reading---
CHAPTER THREE - [ Total Page(s): 2 ]CHAPTER THREE3.0 MATERIALS AND METHODS3.1 Sample Collection Sufficient mushrooms (Agaricus bisporus) was gotten from Igunsin village, Akure north in Ondo State, Nigeria and taken to the Herbarium Service Unit (HSU), Department of Plant Biology, University of Ilorin, Ilorin, Kwara State, Nigeria for authentication with a voucher number of F.H.I. 11295.3.2 Drying and ExtractionThe mushroom samples were cut into pieces using a sharp knife. The pieces were air-dried properly ... Continue reading---
CHAPTER FOUR - [ Total Page(s): 6 ]CHAPTER FOUR4.0 RESULTSThe compounds present in the aqueous and alcoholic extract of Agaricus bisporus were identified by GC-MS analysis after analysis. Aqueous mushroom extract was labelled as A while the alcoholic extract was labelled B. The active principle Molecular Weight (MW), Concentration (%), Molecular Formula (MF), and Retention Time (RT). Nine compounds were identified in the extracts. The prevailing compounds in the aqueous extract were 1-Butanamine, 2-methyl-N- (2-methylbtylid ... Continue reading---
REFRENCES - [ Total Page(s): 2 ]REFERENCESAdams, M., Christen, M., Plitzko, I., Zimmermann, S., Brun, R., Kaiser, M., Hamburger, M. (2010) Antiplasmodial lanostanes from the Ganoderma lucidum mushroom. Journal of Natural Products, 73:897–900.Akindahunsi, A. A., and Oyetayo, F. L. (2012). Nutrient and anti-nutrient distribution of edible mushroom, Pleurotus tuberregium (Fries) Singer. Food Science and Technology, 39(5):548-553.Anthony, M.P., Burrows, J.N., Duparc, S., Moehrle, J.J.,Wells, T.N.C. (2012) The global pipelin ... Continue reading---
