Biochemical Changes In Women With Pre-eclampsia

1.2 Statement Of The Problem

Worldwide, 10 to 15 percent of direct maternal deaths (i.e., resulting from obstetric complications of pregnancy) are associated with preeclampsia/eclampsia (Duley, 2009).Inthe United states, preeclampsia/eclampsia is one of four leading causes of maternal death, along with hemorrhage, cardiovascular conditions, and thromboembolism (Chang et al, 2003, Mackay et al, 2011).Pre-eclampsia is responsible for 15 percent of all preterm births in the USA. Infants of mothers suffering from pre-eclampsia have a five times higher risk of dying than those of mothers without pre-eclampsia, mainly because of preterm birth (Lain and Robert, 2002).Women with pre-eclampsia are at an increased risk for life-threatening events, including placental abruption, acute renal failure, cerebral hemorrhage, hepatic failure or rupture, pulmonary edema, disseminated intravascular coagulation, and progression to eclampsia (Duley,2009).There is approximately one maternal death due to pre-eclampsia-eclampsia per 100,000 live births, with a case-fatality rate of 6.4 deaths per 10,000 cases (Livingston et al, 2003, Mackay et al, 2001). In the Netherlands between 1993 and 2005, pre-eclampsia was the most common cause of maternal death, with 3.5 maternal deaths per 100,000 live births (Schutteet al, 2010).

1.3 Objective of the study

The main objective of this study is to determine the biochemical changes in women with pre-eclampsia. Specifically, the Objectives of this study are:

1. To determine blood pressure of subjects under study.
2. To evaluate renal function (urea, creatinine,uric acid, sodium, potassium).
3. To evaluate liver function(total protein,albumin,ALP,ALT,AST).
4. To evaluate (White blood cells, hemoglobin and platelets,PCV,MCH, MCHC,and MCV).

1.4 Scope Of The Study

The aim of this study on the Biochemical Changes In Women With Pre-Eclampsia was to evaluate the biochemical changes which occur in the serum of pregnant women with pre-eclampsia including renal functions (urea, creatinine, sodium, potassium,anduric acid), liver functions (total protein, albumin, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase), and complete blood count(CBC). it was carried in two hospital in Abuja which are University of Abuja Teaching Hospital and Maitama General Hospital. The study covers between September 2019 to May 2020.