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Anti-plasmodial Property Of Moringa Oleifera Seed Extract On Swiss Mice
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ABSTRACT
Malaria is an increasing worldwide threat, with more than three hundred million infections and one million deaths every year. Due to the emergence of antimalarial drug resistance, the continuous search for antimalarial agents. This study was conducted to determine the antimalarial efficacy of Moringa oleifera Seed extract in Swiss albino mice infected with Plasmodium berghei .After extraction, phytochemical screening and gas chromatographic mass spectrometry (GC-MS) screening of the extract, the mice were grouped into six groups, five per group. Designated as 40% treated with 40mg/kg of the Maringa oliefera seed extract, 60% treated with 60mg/kg, 80% treated with 80mg/kg,100% treated with 100mg/kg and positive control treated with distilled water while negative control was given choloroquone. For the period of 3 days at 12 hours interval. Parasite density was determine by preparing of thick and thin blood film, stain with Giemsa stain and view under microscope to determine the antiplamodial activity of the extract
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TABLE OF CONTENTS - [ Total Page(s): 1 ]TABLE OF CONTENTSContents Title page Certification Dedication Acknowledgements Table of Contents Abstract CHAPTER ONE1.0 Introduction 1.1 Background Study 1.2 Statement of the problem 1.3 Justification 1.4 Aim and Objectives of Study CHAPTER TWO2.0 Literature review 2.1 Definition and history of Malaria 2.1.2 Et ... Continue reading---
CHAPTER ONE - [ Total Page(s): 2 ]A school of thought holds that, the solution to plasmodial resistance development rests in the use of traditional medicinal plants (Liu et al., 2010). Several authors have documented medicinal plants that are used in the treatment of malaria in Ghana and other African countries (Cox, 2010). The story behind the discovery of the artemisinins, as an example, seeks to provide a head way in the discovery of bioactive constituents from medicinal plants for combating malaria (Cox, 2010). ... Continue reading---
CHAPTER TWO - [ Total Page(s): 13 ]Leaves and seed are the parts of the plant of interest. Accordingly, the spatial distribution in planting Moringa oleifera trees is designed to facilitate the relevant harvest and the management practices.For production of leaves, Moringa oleifera plantation can be designed as follows:(i) Intensive production with spacing ranging from 10 cm × 10 cm to 20 cm × 20 cm, harvest interval between 35 to 45 days, irrigation and fertilization are needed;(ii) semintensive production wi ... Continue reading---
CHAPTER THREE - [ Total Page(s): 4 ]Figure 9: Schematic layout of a GC/MS instrument.The stationary phase in Gas Chromatography is commonly a packing of inert, small diameter particles (such as diatomaceous earth) with a nonpolar liquid coating them, or just a liquid coating on the inner surface of the column. This liquid is a very thin layer (0.1 to 5 μm), usually a polydimethyl siloxane (shown below) where some of the –CH3 groups can be altered so as to match the polarity of the analytes. A parameter common ... Continue reading---
CHAPTER FOUR - [ Total Page(s): 5 ] ... Continue reading---
CHAPTER FIVE - [ Total Page(s): 1 ]CHAPTER FIVE5.0 DISCUSSION, CONCLUSION AND RECOMMENDATIONSThis study investigated in-vivo antiplasmodium of Moringa Oleifera seed extract. Related literature review was made considering scholars explanation of the subject matter. Relevant data for the study was generated through laboratory experiments conducted by the researchers. Three hypotheses were postulated and tested for the purpose of the study. The hypotheses were tested in this study using Analysis of Variance (ANOVA) and Duncan Multip ... Continue reading---
REFRENCES - [ Total Page(s): 2 ]ReferencesAbdulkarim, S.M., Long, K., Lai, O.M., Muhammad, S.K.S.and Ghazali, H.M.. (2005). Some physio-chemical properties of Moringa oleifera seed oil extracted using solvent and aqueous enzymatic methods. Food Chemistry. 93:253–263.Abdull Razis, A.F., Ibrahim, M.D. and Kntayya, S.B. (2014). Health benefits of Moringa oleifera. Asian Pac. J. Cancer Prev. 15: 8571–8576.Adeyemi, O.S. and Elebiyo, T.C. (2014). Moringa oleifera supplemented diets prevented nickel-induced nephrotoxici ... Continue reading---
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TABLE OF CONTENTS - [ Total Page(s): 1 ]TABLE OF CONTENTSContents Title page Certification Dedication Acknowledgements Table of Contents Abstract CHAPTER ONE1.0 Introduction 1.1 Background Study 1.2 Statement of the problem 1.3 Justification 1.4 Aim and Objectives of Study CHAPTER TWO2.0 Literature review 2.1 Definition and history of Malaria 2.1.2 Et ... Continue reading---
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