Anti-plasmodial Property Of Moringa Oleifera Seed Extract On Swiss Mice

Hypothesis Two: The anti-plasmodium activities of moringa olifera seed extract on laboratory animals shows no significant effect at different concentration.

Superscripts a, b c and d show that the values are significantly different while all the values bearing the same letter shows no significant different statistically. The result of parasite density at different concentration showed significant reduction in parasite density across the levels of concentrations showed a non-significant difference between the 6 groups in day 0. This is to show that the examined samples were at the same pedestrian in term of parasite density before exposing them to different level of treatment. However, in day 1, significant difference was observed among the concentration levels with positive control having the highest parasite density of 60.00 ± 5.29 followed by 40% concentration with parasite density of 38.00 ± 5.35 and negative control with 29.75 ± 4.86, while low parasite density was noticed at 60%, 80% and 100% concentration. By implication, moringa extract was more effective in day one at 60%, 80% and 100% concentration than 40% concentration, positive control and negative control respectively. In day two and 3, significant differences were also observed across the concentration levels with 60%, 80%, 100% and negative having the same reduction rate in parasite density. There was reduction at 40% concentration, but not as low as others. While other group witness reduction in parasite density, the positive control (placebo) experienced increase in parasite density for lack of treatment.  
Significant reduction in parasite density was also observed across the days from day 1 to day 3 for all the concentrations except for positive control that showed increase with days. For instance, when 40% concentration was given, parasite density reduced from 46.00 ± 6.06 in day 0 to 38.00 ± 5.35 in day 1, 33.00 ± 4.16 in day 2 and 27.25 ± 4.19 in day three respectively. The same level of reduction was noticed at 60% concentration, 80% concentration, 100% concentration and negative control (the group that was given Chloroquine). However, increase in parasite density was noticed in positive control (group that received distilled water). By implication, extracts from the seed of Moringa Oleifera contain anti-plasmodium components that can be used in the treatment of malaria like the way Chloroquine is being used.