-
Nursing Care Study Of A Patient With Nephrogenic Diabetes Insipidus
-
-
-
Healthy kidneys maintain fluid and electrolyte homoeostasis by adjusting urine volume and composition according to physiological needs. The final urine composition is determined in the last tubular segment: the collecting duct. Water permeability in the collecting duct is regulated by arginine vasopressin (AVP). Secretion of AVP from the neurohypophysis is regulated by a complex signalling network that involves osmosensors, barosensors and volume sensors. AVP facilitates aquaporin (AQP)-mediated water reabsorption via activation of the vasopressin V2 receptor (AVPR2) in the collecting duct, thus enabling concentration of urine. In nephrogenic diabetes insipidus (NDI), inability of the kidneys to respond to AVP results in functional AQP deficiency. Consequently, affected patients have constant diuresis, resulting in large volumes of dilute urine.
Primary forms of NDI result from mutations in the genes that encode the key proteins AVPR2 and AQP2, whereas secondary forms are associated with biochemical abnormalities, obstructive uropathy or the use of certain medications, particularly lithium. Treatment of the disease is informed by identification of the underlying cause. Here we review the clinical and diagnostic aspects of NDI, the various aetiologies, current treatment options and potential future developments.
-
-
-
CHAPTER ONE - [ Total Page(s): 1 ]ASSESSMENT OF PATIENT1.0 Introduction Assessment is the first phase of the nursing process. Assessment involves the gathering of information about the health status of the patient, analysis and synthesis of the data, and the making of a clinical judgment (Weller, 2014). According to Stonehouse (2017), information gathered can be either subjective or objective and primary or secondary. Subjective is information that the patient tells the nurse about how he or she is feeling, the levels and sensa ... Continue reading---
-
CHAPTER ONE - [ Total Page(s): 1 ]ASSESSMENT OF PATIENT1.0 Introduction Assessment is the first phase of the nursing process. Assessment involves the gathering of information about the health status of the patient, analysis and synthesis of the data, and the making of a clinical judgment (Weller, 2014). According to Stonehouse (2017), information gathered can be either subjective or objective and primary or secondary. Subjective is information that the patient tells the nurse about how he or she is feeling, the levels and sensa ... Continue reading---
ABSRACT -- [Total Page(s) 1]
Page 1 of 1
ABSRACT -- [Total Page(s) 1]
Page 1 of 1