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The Effects Of Metformin And Diabinese On Female Sex Hormone Of Type 2 Diabetes Mellitus Patients
[UNIVERSITY OF ILORIN TEACHING HOSPITAL (UITH), ILORIN, KWARA STATE] -
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In females FSH and LH act primarily to activate the ovaries to produce estrogen and inhibin which regulate the menstrual cycle and ovarian cycle (Vadakkadath et al., 2005). Estrogen forms a negative feedback loop by inhibiting the production of GnRH in the hypothalamus and Inhibin acts to inhibit activin, which is a peripherally produced hormone that positively stimulates GnRH-producing cells. Follistatin, which is also produced in all body tissue, inhibits activin and gives the rest of the body more control over the axis (Meethal et al., 2009).
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ABSRACT - [ Total Page(s): 1 ]ABSTRACT is coming soon ... Continue reading---
APPENDIX A - [ Total Page(s): 1 ]APPENDIX IQUESTIONNAIRE TO ACCESS THE ANTHROPOLOGIC AND DEMOGRAPHIC INDICES OF PATIENTS WITH TYPE TWO DIABETES MELLITUS ON ANTIDIABETIC DRUGS (METFORMIN AND DIABINESE) ATTENDING UITH ILORIN.INTRODUCTION: I am a final year students of the Department of Medical Laboratory Science, School of Basic Medical Sciences, Kwara State University, Malete, Kwara State. This questionnaire is aimed at accessing the demographic indices of patients with type 2 diabetes mellitus on metformin and diabinese in Ilor ... Continue reading---
APPENDIX B - [ Total Page(s): 1 ]APPENDIX 11REAGENT COMPOSITION FOR ESTROGENEstrogen calibrates, Horseradish Peroxidase Conjugates, Estrogen biotinylated purified rabbit igG conjugates, Tetremethylbenzidine(TMB), wash buffer concentrate, assay buffer, Stop solution.REAGENT COMPOSITION FOR PROGESTERONEProgesterone calibrates, Horseradish Peroxidase Conjugates, Progetarone biotinylated purified rabbit igG conjugates, Tetremethylbenzidine (TMB), wash buffer concentrate, assay buffer, Stop solution. ... Continue reading---
CHAPTER ONE - [ Total Page(s): 2 ]CHAPTER ONEINTRODUCTION1.1 BACKGROUND OF STUDY Diabetes mellitus is a group of metabolic disorders in which a person has high plasma glucose, either because the body does not produce enough insulin, or because cells do not respond to the insulin that is produced. The high plasma glucose produces the classical symptoms of polyuria, polydipsia and polyphagia (Rother, 2007). Type 2 diabetes mellitus, formerly non-insulin dependent diabetes mellitus or adult onset diabetes, is a ... Continue reading---
CHAPTER THREE - [ Total Page(s): 6 ]3.7.2 REAGENT Materials provided with the kit: 1. Antibody-Coated Wells (1 plate, 96 wells) Microtiter wells coated with 1.0 µg/ml streptavidin was packaged in an aluminium.2. Reference Standard Set (1ml/vial) Contains 0, 20, 100, 250, 500 1500,3000 in pg/ml with preservatives.3. Rabbit Anti-estrogen Reagent (6 ml) Contains rabbit anti-estradiol biotinylated rabbit igG conjugate in buffer, yellow dye with preservatives.4. Estradiol enzyme reagent (6 m ... Continue reading---
CHAPTER FOUR - [ Total Page(s): 3 ]Table 4.4: Comparison of biochemical parameters (estrogen, progesterone and fasting blood sugar) between diabetic patients on metformin only and diabetic patients on combined metformin with other drugs (glimepride).Table 4.5 depicts the Pearson correlation of duration of diabetes and BMI with biochemical parameters (estrogen, progesterone and fasting blood sugar) in diabetic patients using antidiabetic drugs (metformin and diabinese).Data indicated a significant correlation between biochemical p ... Continue reading---
CHAPTER FIVE - [ Total Page(s): 2 ]CHAPTER FIVE5.0 DISCUSSIONType 2 diabetes mellitus, formerly known as non-insulin dependent diabetes mellitus or adult onset diabetes, is a metabolic disorder that is characterized by hyperglycemia in the context of insulin resistance and relative insulin deficiency (Vinay et al., 2008). Sex differences and the role of gonadal hormones in modulating insulin sensitivity and glucose tolerance are of increasing interest and importance because of the increasing prevalence of type 2 diabetes me ... Continue reading---
REFRENCES - [ Total Page(s): 4 ]Murali, R. and Saravanan, R. (2012). Antidiabetic effect of d-limonene, a monoterpene in streptozotocin-induced diabetic rats. Biomedical Prevention and Nutrition.2:269-275.Neerati, P., Devde, R., and Gangi, A.K. (2014). Evaluation of the effect of curcumin capsules on glyburide therapy in patients with type-2 diabetes mellitus. Phytotherapeutic. Research. 28:1796-1800.Nelson, L.R. and Bulun, S.E. (2011).Estrogen production and action. Journal of America Academic and Dermatology. 4 ... Continue reading---
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ABSRACT - [ Total Page(s): 1 ]ABSTRACT is coming soon ... Continue reading---