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The Effects Of Metformin And Diabinese On Female Sex Hormone Of Type 2 Diabetes Mellitus Patients
[UNIVERSITY OF ILORIN TEACHING HOSPITAL (UITH), ILORIN, KWARA STATE] -
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CHAPTER FOUR
4.0 RESULT
Table 4.1 depicts the demographic indices between diabetic patients using antidiabetic drugs (cases) (Metformin and Diabinese) and non-diabetic patient (control). Observable data shows a significant (p˂0.05) difference in mean age of the diabetic patients (57.43±1.31) compare to the control (43.30±2.67). The marital status of the diabetic patients and non-diabetic control subjects as indicated on table 4.1 depicts 59(98.4%) of the diabetic patients to be married and 1(1.6%) was single. Also 31(77.5%) of the control subjects were married and 9 (22.5%) were single and this was statistically significant (p˂0.05). The educational status of the diabetic patients were tertiary 27(45%); secondary 3(5%); Primary 9 (15%) and none 21 (35%) and non-diabetic control subjects were tertiary 31(77.5%); primary 1 (2.5%); none education 8 (20%) and none has secondary education and this was statistically significant.
Table 4.1: Comparison of demographic indices between diabetic patients using antidiabetic drugs (cases) (metformin and diabinese) and non-diabetic patient (control).
Table 4.2 shows the anthropometric indices between diabetic patients using antidiabetic drugs (cases) (Metformin and Diabinese) and non-diabetic patients (control). The mean height of the diabetic patients was 170.78±0.62 and that of the control was 168.45±0.82 and this was statistically significant (p˂0.05). The mean weight and BMI of the diabetic patients were 72.53±1.79 and 24.82±0.57 respectively and that of the control patients were 69.70±2.45 and 24.43±0.75 respectively and this was not statistically significant (p>0.05).
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ABSRACT - [ Total Page(s): 1 ]ABSTRACT is coming soon ... Continue reading---
APPENDIX A - [ Total Page(s): 1 ]APPENDIX IQUESTIONNAIRE TO ACCESS THE ANTHROPOLOGIC AND DEMOGRAPHIC INDICES OF PATIENTS WITH TYPE TWO DIABETES MELLITUS ON ANTIDIABETIC DRUGS (METFORMIN AND DIABINESE) ATTENDING UITH ILORIN.INTRODUCTION: I am a final year students of the Department of Medical Laboratory Science, School of Basic Medical Sciences, Kwara State University, Malete, Kwara State. This questionnaire is aimed at accessing the demographic indices of patients with type 2 diabetes mellitus on metformin and diabinese in Ilor ... Continue reading---
APPENDIX B - [ Total Page(s): 1 ]APPENDIX 11REAGENT COMPOSITION FOR ESTROGENEstrogen calibrates, Horseradish Peroxidase Conjugates, Estrogen biotinylated purified rabbit igG conjugates, Tetremethylbenzidine(TMB), wash buffer concentrate, assay buffer, Stop solution.REAGENT COMPOSITION FOR PROGESTERONEProgesterone calibrates, Horseradish Peroxidase Conjugates, Progetarone biotinylated purified rabbit igG conjugates, Tetremethylbenzidine (TMB), wash buffer concentrate, assay buffer, Stop solution. ... Continue reading---
CHAPTER ONE - [ Total Page(s): 2 ]CHAPTER ONEINTRODUCTION1.1 BACKGROUND OF STUDY Diabetes mellitus is a group of metabolic disorders in which a person has high plasma glucose, either because the body does not produce enough insulin, or because cells do not respond to the insulin that is produced. The high plasma glucose produces the classical symptoms of polyuria, polydipsia and polyphagia (Rother, 2007). Type 2 diabetes mellitus, formerly non-insulin dependent diabetes mellitus or adult onset diabetes, is a ... Continue reading---
CHAPTER TWO - [ Total Page(s): 17 ]CHAPTER THREE3.0 MATERIALS AND METHODS3.1 STUDY AREA The study was conducted in the Metropolitan City of Ilorin, Kwara State. Ilorin, the capital city of Kwara State, Nigeria is located on latitude 8o 24’N and 8o 36’N and longitude 4o 10’E and 4o 36’E with an area of about 100Km2 (Kwara State Diary, 1997). 3.2 STUDY POPULATIONThe population of this study was centred on patients with type 2 diabetes mellitus on anti-diab ... Continue reading---
CHAPTER THREE - [ Total Page(s): 6 ]3.7.2 REAGENT Materials provided with the kit: 1. Antibody-Coated Wells (1 plate, 96 wells) Microtiter wells coated with 1.0 µg/ml streptavidin was packaged in an aluminium.2. Reference Standard Set (1ml/vial) Contains 0, 20, 100, 250, 500 1500,3000 in pg/ml with preservatives.3. Rabbit Anti-estrogen Reagent (6 ml) Contains rabbit anti-estradiol biotinylated rabbit igG conjugate in buffer, yellow dye with preservatives.4. Estradiol enzyme reagent (6 m ... Continue reading---
CHAPTER FIVE - [ Total Page(s): 2 ]CHAPTER FIVE5.0 DISCUSSIONType 2 diabetes mellitus, formerly known as non-insulin dependent diabetes mellitus or adult onset diabetes, is a metabolic disorder that is characterized by hyperglycemia in the context of insulin resistance and relative insulin deficiency (Vinay et al., 2008). Sex differences and the role of gonadal hormones in modulating insulin sensitivity and glucose tolerance are of increasing interest and importance because of the increasing prevalence of type 2 diabetes me ... Continue reading---
REFRENCES - [ Total Page(s): 4 ]Murali, R. and Saravanan, R. (2012). Antidiabetic effect of d-limonene, a monoterpene in streptozotocin-induced diabetic rats. Biomedical Prevention and Nutrition.2:269-275.Neerati, P., Devde, R., and Gangi, A.K. (2014). Evaluation of the effect of curcumin capsules on glyburide therapy in patients with type-2 diabetes mellitus. Phytotherapeutic. Research. 28:1796-1800.Nelson, L.R. and Bulun, S.E. (2011).Estrogen production and action. Journal of America Academic and Dermatology. 4 ... Continue reading---
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