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The Effects Of Metformin And Diabinese On Female Sex Hormone Of Type 2 Diabetes Mellitus Patients
[UNIVERSITY OF ILORIN TEACHING HOSPITAL (UITH), ILORIN, KWARA STATE] -
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Table 4.2: Comparison Of Anthropometric Indices between diabetic patients using antidiabetic drugs (Metformin and Diabinese (cases) and non-diabetic patients (control)
Table 4.3 depicts the comparison of biochemical parameters (estrogen, progesterone and fasting blood sugar)in diabetes patient using antidiabetic drugs (cases) (metformin and diabinese) and non-diabetic patients (control). Data depicted a significantly (p˂0.05) reduced level of Estrogen (35.57 ±3.99) and Progesterone (0.78 ±0.06) in the diabetic patients using antidiabetic drugs compared with the non-diabetic control patients (58.72 ±12.31 and 2.49 ±0.64 respectively). However, the diabetic patients on antidiabetic drugs recorded a significantly (p˂0.05) elevated fasting blood sugar level (9.11 ±0.39) compared with the non-diabetic control patients (5.07±0.85).
Table 4.3: Comparison of biochemical parameters (estrogen, progesterone and fasting blood Sugar) in diabetes patient using antidiabetic drugs (cases) (metformin and diabinese) and non-diabetic patients (control).
Table 4.4 depicts the comparison of biochemical parameters (Estrogen, Progesterone and Fasting blood sugar) diabetic patients on Metformin only and diabetic patients on combined metformin with other drugs (glimepride). Data shown an insignificant increased in the level of estrogen (36.15 ±4.33), progesterone (0.78 ±0.61) and fasting blood sugar (9.22 ±0.42) of patients using metformin only compare with patients using metformin with other drugs (29.20 ±3.85; 0.74 ±0.17 and 7.86 ±1.16 respectively).
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ABSRACT - [ Total Page(s): 1 ]ABSTRACT is coming soon ... Continue reading---
APPENDIX A - [ Total Page(s): 1 ]APPENDIX IQUESTIONNAIRE TO ACCESS THE ANTHROPOLOGIC AND DEMOGRAPHIC INDICES OF PATIENTS WITH TYPE TWO DIABETES MELLITUS ON ANTIDIABETIC DRUGS (METFORMIN AND DIABINESE) ATTENDING UITH ILORIN.INTRODUCTION: I am a final year students of the Department of Medical Laboratory Science, School of Basic Medical Sciences, Kwara State University, Malete, Kwara State. This questionnaire is aimed at accessing the demographic indices of patients with type 2 diabetes mellitus on metformin and diabinese in Ilor ... Continue reading---
APPENDIX B - [ Total Page(s): 1 ]APPENDIX 11REAGENT COMPOSITION FOR ESTROGENEstrogen calibrates, Horseradish Peroxidase Conjugates, Estrogen biotinylated purified rabbit igG conjugates, Tetremethylbenzidine(TMB), wash buffer concentrate, assay buffer, Stop solution.REAGENT COMPOSITION FOR PROGESTERONEProgesterone calibrates, Horseradish Peroxidase Conjugates, Progetarone biotinylated purified rabbit igG conjugates, Tetremethylbenzidine (TMB), wash buffer concentrate, assay buffer, Stop solution. ... Continue reading---
CHAPTER ONE - [ Total Page(s): 2 ]CHAPTER ONEINTRODUCTION1.1 BACKGROUND OF STUDY Diabetes mellitus is a group of metabolic disorders in which a person has high plasma glucose, either because the body does not produce enough insulin, or because cells do not respond to the insulin that is produced. The high plasma glucose produces the classical symptoms of polyuria, polydipsia and polyphagia (Rother, 2007). Type 2 diabetes mellitus, formerly non-insulin dependent diabetes mellitus or adult onset diabetes, is a ... Continue reading---
CHAPTER TWO - [ Total Page(s): 17 ]CHAPTER THREE3.0 MATERIALS AND METHODS3.1 STUDY AREA The study was conducted in the Metropolitan City of Ilorin, Kwara State. Ilorin, the capital city of Kwara State, Nigeria is located on latitude 8o 24’N and 8o 36’N and longitude 4o 10’E and 4o 36’E with an area of about 100Km2 (Kwara State Diary, 1997). 3.2 STUDY POPULATIONThe population of this study was centred on patients with type 2 diabetes mellitus on anti-diab ... Continue reading---
CHAPTER THREE - [ Total Page(s): 6 ]3.7.2 REAGENT Materials provided with the kit: 1. Antibody-Coated Wells (1 plate, 96 wells) Microtiter wells coated with 1.0 µg/ml streptavidin was packaged in an aluminium.2. Reference Standard Set (1ml/vial) Contains 0, 20, 100, 250, 500 1500,3000 in pg/ml with preservatives.3. Rabbit Anti-estrogen Reagent (6 ml) Contains rabbit anti-estradiol biotinylated rabbit igG conjugate in buffer, yellow dye with preservatives.4. Estradiol enzyme reagent (6 m ... Continue reading---
CHAPTER FIVE - [ Total Page(s): 2 ]CHAPTER FIVE5.0 DISCUSSIONType 2 diabetes mellitus, formerly known as non-insulin dependent diabetes mellitus or adult onset diabetes, is a metabolic disorder that is characterized by hyperglycemia in the context of insulin resistance and relative insulin deficiency (Vinay et al., 2008). Sex differences and the role of gonadal hormones in modulating insulin sensitivity and glucose tolerance are of increasing interest and importance because of the increasing prevalence of type 2 diabetes me ... Continue reading---
REFRENCES - [ Total Page(s): 4 ]Murali, R. and Saravanan, R. (2012). Antidiabetic effect of d-limonene, a monoterpene in streptozotocin-induced diabetic rats. Biomedical Prevention and Nutrition.2:269-275.Neerati, P., Devde, R., and Gangi, A.K. (2014). Evaluation of the effect of curcumin capsules on glyburide therapy in patients with type-2 diabetes mellitus. Phytotherapeutic. Research. 28:1796-1800.Nelson, L.R. and Bulun, S.E. (2011).Estrogen production and action. Journal of America Academic and Dermatology. 4 ... Continue reading---
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ABSRACT - [ Total Page(s): 1 ]ABSTRACT is coming soon ... Continue reading---