-
The Effects Of Metformin And Diabinese On Female Sex Hormone Of Type 2 Diabetes Mellitus Patients
[UNIVERSITY OF ILORIN TEACHING HOSPITAL (UITH), ILORIN, KWARA STATE]
REFRENCES -- [Total Page(s) 4]
Page 2 of 4
-
-
-
Funnell, M.M., Brown, T.L., Childs, B.P., Haas, L.B., Hosey, G.M.,
Jensen, B., Maryniuk, M., Peyrot, M., Piette, J.D., Reader, D.,
Siminerio, L.M., Weinger, K. and Weiss, M.A. (2012).National standards
for diabetes self-management education. Diabetes Care. 35: 1:101-108.
Garber, A.J. (2012). Obesity and type 2 diabetes: which patients are at risk? Diabetes, Obesity and Metabolism. 14(5):399-408.
Garber,
A.J., Duncan, T.G., Goodman, A.M., Mills, D.J. and Rohlf, J.L.
(2007).Efficacy of metformin in type II diabetes: results of a
double-blind, placebo-controlled, dose-response trial. America Journal
of Medicine. 103:491–497.
Gathercole, L.L., Lavery, G.G. and Morgan,
S.A. (2013).11-hydroxysteroid dehydrogenase 1: translational and
therapeutic aspects. Endocrinology Review. 34:525–555.
Gilmer, T.P.,
Roze, S., Valentine, W.J., Emy-Albrecht, K., Ray, J.A., Cobden, D.,
Nicklasson, L., Philis-Tsimikas, A. and Palmer, A.J.
(2007).Cost-effectiveness of diabetes case management for low-income
populations. Health Services and Research. 42(5):1943-1959.
Häggström,
M. (2014). "Reference ranges for estradiol, progesterone, luteinizing
hormone and follicle-stimulating hormone during the menstrual cycle".
Wiki Journal of Medicine. 1(1): 13-17.
Häggström, M. and Richfield,
D. (2014). Diagram of the pathways of human steroidogenesis. Wiki.
Journal of Medicine. 1(1): 23-30.
Handa, R.J., Ogawa, S., Wang, J.M.
and Herbison, A.E. (2012). Roles for oestrogen receptor β in adult brain
function. Journal of Neuroendocrinology.24(1): 160–173.
Heiman,
J.R., Rupp, H., Janssen, E., Newhouse, S.K., Brauer, M. andLaan, E.
(2011). "Sexual desire, sexual arousal and hormonal differences in
premenopausal US and Dutch women with and without low sexual desire.
Hormone and Behaviour.59(5): 772–779.
Helseth, L.D., Susman, J.L.,
Crabtree, B.F. and O’Connor, P.J. (2009).Primary care physicians’
perceptions of diabetes management: a balancing act. Journal of Family
Practice. 48:37-42.
Hill, R.A., Pompolo, S., Jones, M.E., Simpson,
E.R. and Boon, W.C. (2014). Estrogen deficiency leads to apoptosis in
dopaminergic neurons in the medial preoptic area and arcuate nucleus of
male mice. Molecular Cell and Neuroscience.27(4): 466–476.
Huo, J.,
Bian, X.H., Huang, Y., Miao, Z.C. and Song, L.H. (2017).Inhibitory
effect and mechanism of metformin on human ovarian cancer cells Skov-3
and A2780.Europian Review of Medicine and Pharmacological Science.
21:484-489.
International Diabetes Federation (2012).IDF Diabetes Atlas.5th edition, .McGraw-Hill.PP 446.
Inzucchi,
S.E., Bergenstal, R.M. and Buse, J.B. (2015). Management of
hyperglycemia in type 2 diabetes, 2015: a patient-centered approach.
Update to a position statement of the American Diabetes Association and
the European Association for the Study of Diabetes. Diabetologia.
58:429–442
Inzucchi, S.E., Lipska, K.J., Mayo, H., Bailey, C.J. and
McGuire, D.K. (2014).Metformin in patients with type 2 diabetes and
kidney disease: a systematic review. JAMA. 312:2668–2675.
Kahn, S.E.,
Haffner, S.M. and Heise, M.A. (2006).Glycemic durability of
rosiglitazone, metformin, or glyburide monotherapy. New England Journal
of Medicine. 355:2427–2443.
Kargulewicz, A., SzuliŃska, M., Kujawska-Åuczak, M., Swora-Cwynar, E.,
Musialik, K.., Grzymisł-awska, M., Kręgielsk-a-Narozna, M. and
BogdaŃski, P. (2016). Improvement of serum adiponectin and leptin
concentrations: effects of a low-calorie or isocaloric diet combined
with metformin or orlistat – a prospective randomized open-label trial.
European Review of Medicine and Pharmacological Science. 20:3868-3876.
Kazerooni
T, Sedigheh Dehbashi A, Asadi N, Ghaffarpas and F, KazerooniY (2010).
Effects of metformin plus simvastatin on polycystic ovary syndrome: a
prospective, randomized, double-blind, placebo-controlled study.
Fertility and Sterility. 94(6):2208–2213.
Key, T.J. (2011). Endogenous oestrogens and breast cancer risk in premenopausal and postmenopausal women. Steroids. 76:812-8155.
Key,
T.J., Appleby, P.N. and Reeves, G.K.(2011).Circulating sex hormones and
breast cancer risk factors in postmenopausal women: reanalysis of 13
studies. British Journal of Cancer. 105:709-722.
Khunti, K. and
Davies, M. (2010). Glycaemic goals in patients with type 2 diabetes:
current status, challenges and recent advances. Diabetes, Obesity and
Metabolism. 12(6):474-484.
Knight, K., Badamgarav, E., Henning, J.M.,
Hasselblad, V., Gano, A.D., Ofman, J.J., Weingarten, S.R. (2015).A
Systematic Review of Diabetes Disease Management Programs. America
Journal of Management and Care. 11:242-250.
Knowler, W.C.,
Barrett-Connor, E. and Fowler, S.E. (2012).Reduction in the incidence of
type 2 diabetes with lifestyle intervention or metformin. New England
Journal of Medicine. 346:393–403.
Krishna, S. and Boren, S.A.
(2008).Diabetes self-management care via cell phone: A systematic
review. Journal of Diabetes Science and Technology. 2(3):509-517.
Lombardi, G., Zarrilli, S., Colao, A., Paesano, L., Di Somma, C., Rossi,
F. and De Rosa, M. (2011). Estrogens and health in males. Molecular and
Cellular Endocrinology. 178(12): 51–55.
Lovejoy, J.C. and Sainsbury,
A. (2009).Sex differences in obesity and the regulation of energy
homeostasis. Obesity Review. 10: 154–167.
Mangione, C.M., Gerzoff,
R.B., Williamson, D.F., Steers, W.N., Kerr, E.A., Brown, A.F.,
Waitzfelder, B.E., Marrero, D.G., Dudley, R.A., Kim, C., Herman, W.,
Thompson, T.J., Safford, M.M. and Selby, J.V. (2016). TRIAD Study Group.
The association between quality of care and the intensity of diabetes
disease management programs. Annals of Internal Medicine.
145(2):107-116.
Marieb, E. (2013). Anatomy and physiology. Benjamin-Cummings. pp. 903.
Massaro,
D. and Massaro, G.D. (2014). Estrogen regulates pulmonary alveolar
formation, loss, and regeneration in mice. America Journal of
Physiology.287(6): 1154–1159.
Mather, K.J., Kim, C. and Christophi,
C.A. (2015).Steroid sex hormones, sex hormone-binding globulin, and
diabetes incidence in the diabetes prevention program. Journal of
Clinical Endocrinology and Metabolism. 100:3778–3786.
Mauvais-Jarvis,
F. (2015).Letter to the editor: steroid sex hormones, sex
hormone-binding globulin, and diabetes incidence in the diabetes
prevention program. Journal of Clinical Endocrinology and Metabolism
100:126–127.
McCreight, L.J., Bailey, C.J., Pearson, E.R. (2016). Metformin and the gastrointestinal tract. Diabetologia.59:426–435.
McEwen,
B.S., Gray, J.D. and Nasca, C. (2015).60 years of neuroendocrinology:
redefining neuroendocrinology: stress, sex and cognitive and emotional
regulation. Journal of Endocrinology. 226:67–83.
Mechoulam, R.,
Brueggemeier, R.W. and Denlinger, D.L. (2015)."Estrogens in insects"
(PDF). Cellular and Molecular Life Sciences.40(9): 942–944.
Medrikova,
D., Jilkova, Z.M., Bardova, K., Janovska, P., Rossmeisl, M. and
Kopecky, J. (2012). Sex differences during the course of diet-induced
obesity in mice: adipose tissue expandability and glycemic control.
International Journal of Obesity. (Lond).36:262– 272.
Meethal SV,
Liu T, Chan HW, Ginsburg E, Wilson AC, Gray DN, Bowen RL, Vonderhaar BK,
Atwood CS (2009). "Identification of a regulatory loop for the
synthesis of neurosteroids: a steroidogenic acute regulatory
protein-dependent mechanism involving hypothalamic-pituitary-gonadal
axis receptors". J. Neurochem.110 (3): 1014–27.
Micevych, P.E. and
Kelly, M.J. (2012).Membrane estrogen receptor regulation of hypothalamic
function. Neuroendocrinology.96(2): 103–110.
Miller, K.K.,
Al-Rayyan, N., Ivanova, M.M., Mattingly, K.A., Ripp, S.L., Klinge, C.M.
and Prough, R.A. (2013).DHEA metabolites activate estrogen receptors
alpha and beta. Steroids.78 (1):15–25.
Millar RP, Lu ZL, Pawson AJ,
Flanagan CA, Morgan K, Maudsley SR (2004). "Gonadotropin-releasing
hormone receptors". Endocr. Rev. 25 (2): 235–75..
REFRENCES -- [Total Page(s) 4]
Page 2 of 4
-
-
ABSRACT - [ Total Page(s): 1 ]ABSTRACT is coming soon ... Continue reading---
APPENDIX A - [ Total Page(s): 1 ]APPENDIX IQUESTIONNAIRE TO ACCESS THE ANTHROPOLOGIC AND DEMOGRAPHIC INDICES OF PATIENTS WITH TYPE TWO DIABETES MELLITUS ON ANTIDIABETIC DRUGS (METFORMIN AND DIABINESE) ATTENDING UITH ILORIN.INTRODUCTION: I am a final year students of the Department of Medical Laboratory Science, School of Basic Medical Sciences, Kwara State University, Malete, Kwara State. This questionnaire is aimed at accessing the demographic indices of patients with type 2 diabetes mellitus on metformin and diabinese in Ilor ... Continue reading---
APPENDIX B - [ Total Page(s): 1 ]APPENDIX 11REAGENT COMPOSITION FOR ESTROGENEstrogen calibrates, Horseradish Peroxidase Conjugates, Estrogen biotinylated purified rabbit igG conjugates, Tetremethylbenzidine(TMB), wash buffer concentrate, assay buffer, Stop solution.REAGENT COMPOSITION FOR PROGESTERONEProgesterone calibrates, Horseradish Peroxidase Conjugates, Progetarone biotinylated purified rabbit igG conjugates, Tetremethylbenzidine (TMB), wash buffer concentrate, assay buffer, Stop solution. ... Continue reading---
CHAPTER ONE - [ Total Page(s): 2 ]CHAPTER ONEINTRODUCTION1.1 BACKGROUND OF STUDY Diabetes
mellitus is a group of metabolic disorders in which a person has high
plasma glucose, either because the body does not produce enough insulin,
or because cells do not respond to the insulin that is produced. The
high plasma glucose produces the classical symptoms of polyuria,
polydipsia and polyphagia (Rother, 2007). Type 2 diabetes mellitus,
formerly non-insulin dependent diabetes mellitus or adult onset
diabetes, is a ... Continue reading---
CHAPTER TWO - [ Total Page(s): 17 ]CHAPTER THREE3.0 MATERIALS AND METHODS3.1 STUDY AREA The study was conducted in the Metropolitan City of Ilorin, Kwara State. Ilorin, the capital city of Kwara State, Nigeria is located on latitude 8o 24’N and 8o 36’N and longitude 4o 10’E and 4o 36’E with an area of about 100Km2 (Kwara State Diary, 1997). 3.2 STUDY POPULATIONThe population of this study was centred on patients with type 2 diabetes mellitus on anti-diab ... Continue reading---
CHAPTER THREE - [ Total Page(s): 6 ]3.7.2 REAGENT Materials provided with the kit: 1.
Antibody-Coated Wells (1 plate, 96 wells) Microtiter wells coated with
1.0 µg/ml streptavidin was packaged in an aluminium.2. Reference Standard Set (1ml/vial) Contains 0, 20, 100, 250, 500 1500,3000 in pg/ml with preservatives.3.
Rabbit Anti-estrogen Reagent (6 ml) Contains rabbit anti-estradiol
biotinylated rabbit igG conjugate in buffer, yellow dye with
preservatives.4. Estradiol enzyme reagent (6 m ... Continue reading---
CHAPTER FOUR - [ Total Page(s): 3 ]Table 4.4: Comparison of biochemical parameters (estrogen, progesterone and fasting blood sugar) between diabetic patients on metformin only and diabetic patients on combined metformin with other drugs (glimepride).Table 4.5 depicts the Pearson correlation of duration of diabetes and BMI with biochemical parameters (estrogen, progesterone and fasting blood sugar) in diabetic patients using antidiabetic drugs (metformin and diabinese).Data indicated a significant correlation between biochemical p ... Continue reading---
CHAPTER FIVE - [ Total Page(s): 2 ]CHAPTER FIVE5.0 DISCUSSIONType 2 diabetes mellitus, formerly known as non-insulin dependent diabetes mellitus or adult onset diabetes, is a metabolic disorder that is characterized by hyperglycemia in the context of insulin resistance and relative insulin deficiency (Vinay et al., 2008). Sex differences and the role of gonadal hormones in modulating insulin sensitivity and glucose tolerance are of increasing interest and importance because of the increasing prevalence of type 2 diabetes me ... Continue reading---
