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The Effect Of Garcinia Kola Extract (bitter Kola) On High Blood Glucose (diabetes Mellitus) And Serum Cholesterol Level In Alloxan Induced Diabetic Albino Rat
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Diabetes mellitus is a deliberating disorder in which strick glycemic control and prevention of associated complications are very important. In view of the increasing interest in the use of plant source for the treatment of diabetes mellitus, the effect of Garcinia kola extract in blood glucose and serum cholesterol level on alloxan induced diabetic albino rat were investigated.In this research work sixteen albino rat of wistar strain were divided into four groups of four rat in each group. Group one serves as negative control which were non diabetic, and they receives normal poultry feed and 3% tween 80, group two and three which serves as the test were induced alloxan monohydrate to make them diabetic and they received 200mg/kg body weight and 500mg/kg bosdy weight of the ethanolic extract of Garcinia kola respectively and group four serves as standard group, they were induced alloxan monohydrate to be diabetic and they received 100mg/kg of standard drug (Glucoghage 500mg/kg). Alloxan monohydrate caused significant increase in the level of blood glucose, the level of blood glucose were monitored in test and standard groups after oral administration of the garcinia kola extract. The Blood glucose significantly lowered in the test groups than that of the standard drug, and there is also a decrease in serum cholesterol of the test groups than that of the standard group. This shows that Garcinia kola extract offered significant anti-diabetic and anti cholesterol effect in the rats.
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CHAPTER ONE - [ Total Page(s): 2 ]CHAPTER ONEINTRODUCTION1.1Background of the Study
Diabetes mellitus is the most important disease involving the endocrine
pancreas. Its major Manifestations are disordered metabolism and
inappropriate hyperglycemia or high level of blood glucose. Despite all
the conventional drugs presently available, the progressive
deterioration of diabetes control is such that treatment is still
insufficient. Insufficiency of current therapies for the treatment of
diabetes, combined with b ... Continue reading---
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CHAPTER ONE - [ Total Page(s): 2 ]CHAPTER ONEINTRODUCTION1.1Background of the Study
Diabetes mellitus is the most important disease involving the endocrine
pancreas. Its major Manifestations are disordered metabolism and
inappropriate hyperglycemia or high level of blood glucose. Despite all
the conventional drugs presently available, the progressive
deterioration of diabetes control is such that treatment is still
insufficient. Insufficiency of current therapies for the treatment of
diabetes, combined with b ... Continue reading---
ABSRACT -- [Total Page(s) 1]
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ABSRACT -- [Total Page(s) 1]
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