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The Effect Of Garcinia Kola Extract (bitter Kola) On High Blood Glucose (diabetes Mellitus) And Serum Cholesterol Level In Alloxan Induced Diabetic Albino Rat
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CHAPTER ONE
INTRODUCTION
1.1Background of the Study
Diabetes mellitus is the most important disease involving the endocrine
pancreas. Its major Manifestations are disordered metabolism and
inappropriate hyperglycemia or high level of blood glucose. Despite all
the conventional drugs presently available, the progressive
deterioration of diabetes control is such that treatment is still
insufficient. Insufficiency of current therapies for the treatment of
diabetes, combined with both a lack of trust in conventional medical
treatment and an inability of the economy to absorb the cost of
pharmaceuticals have created a public interest in dietary supplements.
Diabetes
mellitus is a metabolic disease that involve problem with the hormone
insulin (Enrich, 2000). It is characterized by hyperglycemia, increase
protein breakdown, pyuria, weight loss, coma etc. Several fractions such
as high calorie diet intake, age, lack of exercise, alcohol consumption
and genetic predisposition have been linked with diabetic disease
(Enrich, 2000). Diabetes mellitus is among the most common disorder in
developed and developing countries. The disease is increasing rapidly in
many part of the world. In 2000, according to WHO (World Health
Organization),at least 171 million people worldwide suffer from from
diabetes which correspond to 2.8% of world population. This figure is
expected to double in the year 2030. Hyperglycemia in diabetic patients
is associated with alternation in glucose and lipid metabolism and
modification in liver enzyme levels (Jenson and Stenders,1998). Diabetes
mellitus has been recognized as a risk factor for cardiovascular
Diseases(CVD), such as stroke, heart attarck, atherosclerosis
(Adaramoye and Forambi, 2005). About 75% of death among men and 57% of
death among women with diabetes mellitus are attributable to
cardiovascular diseases.
Garcinia kola otherwise called bitter kola
belongs to the family Guttiferae . It is found mainly in the tropical
rain forest region of the central and West Africa . It is predominant
in the rainforest belt of southern Nigeria. The seed are edible and are
consumed as adjuvant to the true kola (Kola nitida) and for medicinal
purposes. Garcinia kola is regaSrded as a wonderful kola because
every part of it has a medicinal importance. Garcinia kola is used in
folklore remedies for the treatment of ailments such as liver disorders,
diarrhea, laryngitis, bronchitis and gonorrhea . It is also used in the
treatment of jaundice, high fever and purgative. Garcinia kola is
masticatory and used to prevent and relieve colic, chest colds, and
cough and can as well be use to treat headache . Garcinia kola has also
anti-fungal and ant-microbial effect (Adaramoye, et al., 2002).
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ABSRACT - [ Total Page(s): 1 ]Diabetes mellitus is a deliberating disorder in which strick glycemic control and prevention of associated complications are very important. In view of the increasing interest in the use of plant source for the treatment of diabetes mellitus, the effect of Garcinia kola extract in blood glucose and serum cholesterol level on alloxan induced diabetic albino rat were investigated.In this research work sixteen albino rat of wistar strain were divided into four groups of four rat in each group. Grou ... Continue reading---
