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The Effect Of An Antihypertensive Drug - Nifedipine On Some Biochemical Parameters In Rats
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CHAPTER ONE
1.0 INTRODUCTION
1.1 Background of the Study
Young people develop contain habits for the sake of acceptance in a group. They resort to dangerous habits such as smoking, alcoholism and drug taking for so many reasons such as; helping them to cope with the problems, fear and pressure of everyday life (Brook et al 2001). Some use drugs as s means of escape from realities in life, to reduce anxieties, out of curiosity, while some turn to it in a bid to challenge authority.
Teenagers may be involved with legal or illegal drugs in various ways. Experimentation with drugs during adolescence is common. Unfortunately, teenagers often do not see the link between their actions today and the consequences tomorrow. They also have a tendency to feel indestructible and immune to the problems that others experience. Using alcohol and tobacco at a young age increases the risk of using other drugs later. Some teens will experiment and stop or continue to use occasionally, without significant problems. Others will develop a dependency or addiction, often moving on to more dangerous drugs and causing significant harm to themselves and possibly others (Ibanga 2000).
As Jones, 2006 observes, excessive use of drugs and alcohol work to the determent of important social institutions, such as schools and threaten the smooth functioning of our social system. It is a well established fact that smoking is injurious to health and extensive studies have shown that smokers have an increase risk of disability, illnesses and death from a number of diseases on conditions.
Drug abuse has increased drastically in recent years and the problem is becoming more serious, especially among young teens that are predominantly found in the secondary schools (Anthony et al 1995). The average age of first marijuana use is 14, and alcohol use can start before age 12. The use of alcohol and marijuana in secondary schools has become common. Drug use is associated with a variety of negative consequences, including increased risk of serious drug use later in life, school failure and poor judgement, which may put teens at risk of accidents, violence, unplanned and unsafe sex, and suicide.
In the words of Kipke, (1999), teenagers at risk for developing serious alcohol and drug problems include those: with a family history of substance abuse, who are depressed, who feel like they do not fit in or are out of the mainstream. Teenagers abuse a variety of drugs– legal and illegal, such drugs include; tobacco, alcohol, inhalants, marijuana stimulants, cocaine, depressants, heroin, steroids, MDMA (ecstasy), GHB,rohypnol (rophies), ketamine, met-amphetamine, LSD, club drugs, etc. These drugs are either ingested, smoked, injected or snorted.
Adolescents who abuse drugs present these kinds of behaviours; Physical- fatigue, repeated health complaints, frequent flu-like episodes, chest pains, “allergy †symptoms, chronic cough, red and glazed eyes, impaired ability to fight off common infections and fatigue, impaired short term memory, change in health or grooming; Emotional personality change, sudden mood changes, irritability, anger, hostility, irresponsible behaviour, low self-esteem, poor judgement, feelings of loneliness, depression, apathy or general lack of interest, change in personal priorities; Family Relationships-decreased interest in the family and family activities, starting arguments, negative attitude, verbal (or physical) mistreatment of younger siblings, breaking rules, withdrawing from family, secretiveness, failure to provide specific answer to questions about activities, personal time that is unaccounted for, lying and dishonesty, unexplained disappearance of possessions in the home, increased money or poor justification of how money was spent; School activities –decreased interest, negative attitude, unexplained drop in grades, irregular school attendance, truancy, discipline problems, not returning home after school; Peer Relationships- dropping old friends and picking new group of friends (new friends who make poor decisions and are not interested in school or family activities ), changes to a different style in dressing and music, attending parties with no parental supervision (Jones 2006).
Teenagers might tell themselves they will only try a drug once, but many teens find themselves under continual peer pressure to continue to experiment with drugs and “join the partyâ€. Most teens do not start using drugs expecting to develop a substance abuse problem, and while most teens probably see their drug use as a casual way to have fun, there are negative effects that are as a result of these use and abuse of alcohol and other drugs. The biggest consequence to casual drug use can be that it develops unto a true addiction. Most teens do not think that they will become addicted, and simply use drugs or alcohol to have a good time and be more like friends. (Gullets et al 1994).
If the mentioned signs and problems are noticed in adolescents, help should be sought with immediate effect by talking to the teen about it and seeking to establish if they are actually into drug use, how they started and why, and encourage them to get help. Treatment programme should be found for them by consulting a physician to rule out physical causes of drug use, followed or accompanied by a comprehensive evaluation by a mental health professional (Johnson et al 2001).
As the days come by, incidents of youths dropping out of secondary schools for no just cause, becoming mentally deranged and behaving abnormally abound all over the streets in our society. This has given so much concern and a need for an urgent step to be taken to see how this ugly incidence could be addressed since the adverse effects of these drugs usage such as stealing, burglary, armed robbery and other violent and heinous crimes are felt here and there. This as a societal ill raises too many questions than answers, thus raising curiosity as a necessity to carrying out this research.
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