Insilico Identification 0f Putative Drug Targets In Staphylococcus Aureus

Any gene necessary for the viability of a pathogenic organism may be a possible drug target, particularly when the sequence of that gene has little or no similarity to those of the host and the pathogen can be effectively used for designing a drug specifically targeting the pathogen. Detection of bacterial genes that are non-homologous to human genes and are essential for the survival of the pathogen represents a promising means of identifying novel drug targets (sakharkar et al.,2004).

  The computation approach has been used to investigate novel drug targets in other pathogenic organisms such as pseudomonas aeruginosa (sakharkar et al., 2004; perumal et al., 2007) and in Helicobacter pylori (dutta et al., 2006). In their study, the search for potential vaccine and drug targets against staphylococcus aureus was carried out by in silico.

AIM AN OBJECTIVES 

AIM

To identify different drug target enzymes in staphylococcus aureus.

PRIMARY OBJECTIVES

1. To extract protein from NCBI( national center for biotechnology information) database in staphylococcus aureus.

2. To identify non-human homolog proteins to serve as drug target.

3. To find and locate those essential genes of staphylococcus aureus that play important roles in the normal functioning of the bacterium with the host and to short list them in the view of drug targeting.